Microdialysis Sampling: Analytical Chemistry-Based Improvements and Applications

Microdialysis sampling was originally developed to directly collect low molecular weight hydrophilic solutes including neurotransmitters and energy metabolites from rodent brain.  Over the course of nearly 50 years, the technique has seen little change.  However, the analytes that are of interest for in vivo collection have become quite diverse in terms of molecular weight distributions and polarity.  Over the years, our research group has focused on several microdialysis sampling improvements for a variety of measurements.  These have included various capture agents such as antibodies or affinity-agent immobilized beads in the past to our current work with covalent organic frameworks (COFs) to improve microdialysis sampling extraction efficiency.  More recently, we have heavily invested in using 3D printing to create novel microdialysis sampling probes.  Finally, we are also working on aspects of using microdialysis sampling for understanding various dynamic aspects of soil chemistry.