1567 Irving Hill Rd
Lawrence, KS 66045
- Bioinorganic Chemistry
- Biomimetic Chemistry
- Biophysical Chemistry
Nature uses metalloenzymes containing Mn, Fe, or Cu and oxidants such as molecular oxygen and hydrogen peroxide to carry out remarkable oxidative transformations that are both vital for life and fascinating from a fundamental perspective. Such reactions also serve as inspiration for synthetic chemists, as catalytic processes that utilize earth-abundant metals are less expensive and more environmentally benign than conventional process that employ precious-metals. Our research focuses on using synthetic model complexes to understand the chemical reactions that are critical to the function of both metalloenzymes and earth-abundant metal catalysts. These reactions include activation of dioxygen (O2) and hydrogen peroxide (H2O2) and the cleavage of C-H and O-H bonds by high- and mid-valent metal-oxygen species. To achieve these goals, the Jackson lab uses a combination of i) synthetic and kinetic methods to generate and characterize the reactivity patterns of metal ion complexes, ii) detailed spectroscopic characterization of transition-metal species, and iii) computational chemistry. These combined efforts allow us to identify geometric and electronic properties of transition-metal complexes that influence chemical reactivity.
Spectroscopic methods used in our research include electronic absorption (UV-vis), electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD), and X-ray absorption (XAS) spectroscopies. We also employ NMR methods to probe the solution structures of paramagnetic complexes. These tools are particularly powerful when used in conjunction with computational methods, as they permit the characterization of the geometric and electronic structures of fleeting intermediates too unstable to be characterized using standard crystallographic methods. Our lab also used kinetic studies to probe the reaction mechanisms of our complexes. By applying this three-pronged approach to bio-inspired transition-metal complexes, we gain detailed insight into how nature uses molecular oxygen and earth-abundant metals to oxidize substrates and apply this knowledge to develop transition metal complexes that can perform green oxidation reactions.
Selected Publications —
Singh, P.; Stewart-Jones, E.; Denler, M. C.; Jackson, T.A., Mechanistic insight into oxygen atom transfer reactions by mononuclear manganese(iv)–oxo adducts Dalton Transactions 2021, Just Accepted
Kwon, Y.; Lee, Y.; Jackson, T. A.; Wang, D., Crystal Structure and C–H Bond-Cleaving Reactivity of a Mononuclear CoIV–Dinitrate Complex Journal of American Chemical Society 2020, 142 (31), 13435-13441.
Mayfield, J. R.; Grotemeyer, E. N.; Jackson, T. A., Concerted proton–electron transfer reactions of manganese–hydroxo and manganese–oxo complexes Chemical communications 2020, 56 (65), 9238-9255.
Zolnhofer, E. M.; Wijeratne, G. B.; Jackson, T. A.; Fortier, S.; Heinemann, F. W.; Meyer, K.; Krzystek, J.; Ozarowski, A.; Mindiola, D. J.; Telser, J., Electronic Structure and Magnetic Properties of a Titanium(II) Coordination Complex Inorganic Chemistry 2020, 59 (9), 6187-6201.
Chen, X.; Rice, D. B.; Danby, A. M.; Lundin, M. D.; Jackson, T. A.;Subramaniam, B., Experimental and computational investigations of C–H activation of cyclohexane by ozone in liquid CO2 Reaction Chemistry & Engineering 2020, 5 (4), 793-802.
Rice, D. B.; Grotemeyer, E. N.; Donovan, A. M.; Jackson, T. A., Effect of Lewis Acids on the Structure and Reactivity of a Mononuclear Hydroxomanganese(III) Complex Inorganic Chemistry 2020, 59 (5), 2689-2700.
Massie, A. A.; Denler, M. C.; Singh, R.; Sinha, A.; Nordlander, E.; Jackson, T. A., Structural Characterization of a Series of N5-Ligated Mn-IV-Oxo Species Chemistry-A European Journal 2020, 26 (4), 900-912.
Awards & Honors —
Silver Anniversary Teaching Award, University of Kansas
NSF CAREER Award
ACS Young Investigator Award – Division of Inorganic Chemistry
Inorganic Chemistry Research Award, University of Wisconsin-Madison