Richard L. Schowen
Organic chemistry and enzymology: reaction mechanisms, bioorganic chemistry, catalysis, isotope effects
Professor Schowen has closed his research groups and is publishing results from those groups and his work with colleagues at Kansas and elsewhere. The latter programs included studies of antiparasitic drug design for S-adenosylhomocysteine hydrolase, led by R.T. Borchardt; protium-deuterium exchange in the amorphous solid state as a measure of protein mobility, led by Elizabeth M. Topp (Purdue University); and quantum tunneling and isotope effects, led by H.-H. Limbach (Free University of Berlin).
Selected Publications —
Qing-Shan Li; Sumin Cai; Jianwen Fang; Ronald T. Borchardt; Krzysztof Kuczera; C. Russell Middaugh; Richard L.Schowen, Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix-18 stability, Biochemistry 2008, 47, 4983-4991.
K. Anandarajah, K.B. Schowen, and R.L. Schowen, Hydrogen tunneling in glucose oxidation by the archaeon Thermoplasma acidophilum, Zeitschrift für physikalische Chemie 2008, 222, 1333-1347.
R.L. Schowen, Strengths and weaknesses of model reactions for the assessment of tunnelling in enzymic reactions, Ch. 13 in Quantum Tunnelling in Enzyme-Catalysed Reactions (R.K. Allemann and N.S. Scrutton, eds.), Royal Society of Chemistry, London, 2009, pp 291-313.
Sumin Cai, Qing-Shan Li, Jianwen Fang, Ronald T. Borchardt, Krzysztof Kuczera, C. Russell Middaugh, and Richard L. Schowen, The Rationale for Targeting the NAD/NADH Cofactor Binding Site of Parasitic S-Adenosyl-L-homocysteine Hydrolase for the Design of Anti-parasitic Drugs, Nucleosides, Nucleotides, and Nucleic Acids, 2009, 28, 485-503.
Qing-Shan Li, Sumin Cai, Jianwen Fang, Ronald T. Borchardt, Krzysztof Kuczera, C. Russell Middaugh, and Richard L. Schowen, Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-Adenosylhomocysteine hydrolase, Nucleosides, Nucleotides, and Nucleic Acids, 2009, 28, 473-484.
Hans-Heinrich Limbach, K. Barbara Schowen, Richard L. Schowen, Heavy-atom motions and tunneling in hydrogen transfer reactions: the importance of the pre-tunneling state, J. Phys.Org. Chem., 2010, 23, 586-605.
Sumin Cai; Jianwen Fang, Qing-shan Li, Ronald T. Borchardt, Krzysztof Kuczera, C. R. Middaugh, Richard L. Schowen, Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. The role of lysyl and tyrosyl residues of the C-terminal extension, Biochemistry, 2010, 49, 8434-41.