Paul R. Hanson
- Chancellors Club Teaching Professor
1567 Irving Hill Rd
Lawrence, KS 66045
- Synthetic methods
- Natural product synthesis
- Transition metal-catalyzed methods
- Asymmetric methods
- S- and P-heterocycles
- Immobilized reagent development
- Drug discovery and delivery
- Chemical methods for library development.
The major goal of our research program is the development of new synthetic methods for use in drug discovery and natural product synthesis. In particular, we have focused our attention on the utilization of transition metal-catalyzed methods as a means to produce new heterocycles containing sulfur and phosphorus (S- and P-heterocycles) that exhibit both biological and synthetic utility. Central to this goal is the development of phosphorus tethered processes in the synthesis of complex, biologically relevant natural products.
Another facet of our program is aimed at the development of immobilized reagents for use in drug discovery. We are currently employing ring-opening metathesis (ROM) polymerization to generate high-load oligomers with tuneable properties as tools for organic synthesis and library production. We have a long-standing interest in the establishing new chemical methods for library development.
Selected Publications —
Dissanayake, G.C., Ndi, C.N., Markley, J.L., Martinez, J.B., and Hanson, P.R. Total Synthesis of Sanctolide A and Formal Synthesis of (2S)-Sanctolide A. J. Org. Chem. 2023, 88, 805-817. DOI: 10.1021/acs.joc.2c01922
Javed, S.; Ganguly, A.; Dissanayake, G. C.; Hanson, P. R. An iterative phosphate tether-mediated approach for the synthesis of complex polyols subunits. Org. Lett. 2022, 24, 16–21. Equal contributions amongst authors. Online Publication date Dec. 13, 2021.
Jun, J. J. H., Duscharla, D., Ummanni, R., Hanson, P. R., Malhotra, S. Investigation on the anti-cancer activity of symmetric and unsymmetric cyclic sulfamides. ACS Med. Chem. Lett.2021, 12, 202–210.
Ganguly, A.; Javed, S.; Bodugam, M.; Dissanayake, G.; Chegondi, R.; Hanson, P. R. Synthesis of the C1−C16 Polyol-Containing Macrolactone of 13-Desmethyl Lyngbouilloside, an Unnatural Analog of the Originally Assigned Structure of (−)-Lyngbouilloside. Israeli J. Chem. 2021, 61,401–408.