Graduate Courses in Chemistry
A course for beginning graduate students with particular emphasis on issues relevant to the chemical sciences. Topics will include scientific ethics, scientific misconduct, record keeping, authorship, and the responsibilities of a scientist. Group discussions, particularly centered around case studies, will be a significant component of the course.
Review of all complex variable theory; introduction to the partial differentiation equations of physics; Fourier analysis; and special functions of mathematical physics. (Same as PHSX 718.) Prerequisite: Two semesters of junior-senior mathematics.
An introductory graduate level course in analytical chemistry, in which the principles of electrochemistry, spectroscopy and separation science are utilized to solve analytical problems in inorganic, organic and biochemistry. Prerequisite: an undergraduate course in analytical chemistry, a year of organic and a year of physical chemistry.
An examination of the basic foundations of coordination chemistry and organometallic chemistry including symmetry methods, bonding, magnetism, and reaction mechanisms. Prerequisite: Two semesters of organic chemistry and one semester of physical chemistry in which quantum chemistry is introduced. The latter course may be taken concurrently with CHEM 730.
A consideration of the structural features and driving forces that control the course of chemical reactions. Topics will include acid and base properties of functional groups; qualitative aspects of strain, steric, inductive, resonance, and solvent effects of reactivity; stereochemistry and conformations; an introduction to orbital symmetry control; basic thermodynamic and kinetic concepts; and an overview of some important classes of mechanisms. Prerequisite: Two semesters of undergraduate organic chemistry and one semester of physical chemistry or concurrently.
The use of techniques such as infrared, nuclear magnetic resonance, and ultraviolet spectroscopy, and mass spectrometry for elucidating the structure of organic molecules. A lecture and workshop course. Prerequisite: CHEM 626 and CHEM 627.
An introduction to the basic principles of quantum theory relevant to atomic and molecular systems. Topics include operators and operator algebra, matrix theory, eigenvalue problems, postulates of quantum mechanics, the Schrodinger equation, angular momentum, electronic structure, molecular vibrations, approximation methods, group theory, and the foundations of spectroscopy. Prerequisite: Two semesters of physical chemistry.
A comprehensive introduction to the application of chemistry to address problems in biology at the molecular level. The fundamentals of biomolecules (nucleic acids, proteins, lipids and carbohydrates) and techniques of chemical biology research will be discussed.
A study of the overall concept of central nervous system functioning. A brief introduction to neuroanatomy and neurophysiological techniques as well as a relatively detailed discussion of the chemistry of neurotransmitters is included. (Same as BIOL 775, MDCM 775, NURO 775, P&TX 775, and PHCH 775.) Prerequisite: One year of undergraduate organic chemistry.
Original investigation in chemistry at the graduate level. (Graded A-F)
Colloquia on various topics of current interest in chemistry are presented by students, faculty, and visiting scholars.
An advanced treatment of analytical separations techniques. The theory of separation science will be augmented with discussion of practical aspects of instrumentation and experiment design. Prerequisite: CHEM 720.
An advanced treatment of selected electroanalytical techniques and methodology. Prerequisite: CHEM 720 or its equivalent.
General concepts of encoding chemical information as electromagnetic radiation; major instrumental systems for decoding, interpretation, and presentation of the radiation signals; atomic emission, absorption, and fluorescence; ultraviolet, visible, infrared, and microwave absorption; molecular luminescence; scattering methods; mass spectrometry; magnetic resonance; automated spectrometric systems. Prerequisites: CHEM 720.
An introduction to mass spectrometry. The various ionization techniques and mass analyzers will be discussed, and many examples of different mass spectrometric applications will be introduced. Prerequisite: CHEM 720.
A course covering important aspects in modern chemical measurement with particular emphasis placed on bioanalysis. This course will survey the modern analytical challenges associated with the ongoing efforts in genomics and proteomics and discuss future trends in methods in instrumentation. Prerequisite: CHEM 720.
An introduction of quantum and group theories in relation to bonding and physicochemical properties of inorganic substances. Topics include vibrational and electronic spectroscopies, magnetism, and inorganic photochemistry. Prerequisite: CHEM 730.
Mechanistic aspects of transition metal chemistry including substitution reactions, electron transfer reactions, rearrangement reactions, ligand reactions and inorganic photochemistry. Principles and applications of heterogeneous and homogeneous catalytic processes emphasizing catalysis at transition metal centers. Prerequisite: CHEM 730.
An examination of the methods used to probe the mechanisms of organic reactions and of the chemistry of some important reactive intermediates. Topics will include isotope effects, kinetics, linear free energy relationships, solvent effects, a continuing discussion of orbital symmetry, rearrangements, carbocations, carbanions, carbenes, radicals, excited states, and strained molecules. Prerequisite: CHEM 740.
A discussion of fundamental reactions for the formation of carbon-carbon bonds, oxidation, reduction, and functional group interchange. Prerequisite: CHEM 740.
A course designed to develop a student’s ability to apply fundamental concepts of mechanistic organic and organometallic chemistry, physical organic chemistry, bioorganic chemistry, synthetic organic reactions and techniques for structure elucidation. Students will propose solutions to practice problems mimicking challenges that arise in contemporary research in organic chemistry. The format includes interactive problem-solving discussions led by faculty and peers and monthly written examinations. May be repeated up to three times until the student has passed at least four of the written exams. Prerequisite: CHEM 740 or permission of instructor.
The advanced mathematical and physical principles of quantum mechanics relevant to atomic and molecular systems. Topics may include abstract vector spaces and representations, time-dependent quantum dynamics, electronic structure theory, density matrices, second-quantization, advanced group theory, path integrals, and scattering theory. Prerequisite: CHEM 750 or its equivalent.
Thermodynamics and introduction to equilibrium statistical mechanics with emphasis on problems of chemical interest. The course consists of two roughly equal parts: 1) An advanced overview of the laws and concepts of thermodynamics with application to specific problems in phase and chemical equilibria and 2) An introduction to equilibrium statistical mechanics for both classical and quantum systems. Prerequisite: CHEM 750 or its equivalent.
A study of the rates, mechanisms, and dynamics of chemical reactions in gases and liquids. Topics include an advanced overview of classical kinetics, reaction rate theories (classical collision theory, transition state theory and introductory scattering theory), potential energy surfaces, molecular beam reactions, photochemistry, Marcus electron transfer theory and other areas of current interest. Prerequisite: CHEM 750 or its equivalent.
Quantitative molecular spectroscopy and its chemical applications. The basic principles of the molecular energy levels, selection rules and spectral transition intensities will be discussed and applied to rotational, vibrational, electronic, and nuclear magnetic spectroscopy. Linear and nonlinear spectroscopies will be addressed. Prerequisite: CHEM 750 or its equivalent.
Original investigation in chemistry at the graduate level. Prerequisite: Advancement to doctoral candidacy. (Graded S/U.)
A survey of metalloproteins and metalloenzymes, their structures and functions, including recent advances in biomimetic modeling, small molecule activation in biological systems, and related physical methods. Prerequisite: CHEM 832.
A survey of important techniques in organic chemistry with respect to scope, limitations, mechanism, and stereochemistry. Emphasis will be placed on new synthetic methods and application of such methods to the synthesis of structurally interesting compounds, particularly natural products. Prerequisite: CHEM 842.
Advanced equilibrium statistical mechanics and introduction to nonequilibrium statistical mechanics. Topics include: the theory of liquids, critical phenomena, linear response theory and time correlation functions, Langevin dynamics, and molecular hydrodynamics. (Same as PHSX 971.) Prerequisite: CHEM 852 or its equivalent.
A course covering special advanced topics in chemistry not included in other graduate courses. One or more topics will be covered in a given semester and an announcement of the course content and prerequisites will be made at the end of the previous semester. This course may be taken more than once when the topic varies.