- B.S. 1968, Ph.D., 1974, Temple University
- Postdoctoral Research Fellow, The Ohio State University, 1974-1975.
Areas of Specialization
Supramolecular and Traditional Coordination Chemistry
Research in the Bowman-James group involves the strategic design organized molecular frameworks as selective receptors for anions and as ligands for transition metal ions. Our interest in these areas stems from potential environmental and biological applications in sensing, separations, catalysis, and biomimetic chemistry. We also seek to examine the similarities (and differences) between anion supramolecular chemistry and transition metal coordination chemistry. In this particular endeavor we are exploring the same ligands as frameworks for coordinating both anions and transition metals. While a major difference between the two types of chemistry are that anion binding mostly involves hydrogen bonding interactions and transition metal binding involves coordinate covalent (or dative) bonds. Our anion efforts have focused on targeting nucleotides and other phosphate-containing species, as well as small organic and inorganic ions as guests. As such we have explored the capture of oxo anions, halides, pseudo-halides, and carboxylates, ranging in size and shape from relatively compact spherical to linear, trigonal planar, tetrahedral, and expanded pseudo-linear anions.
More recently our attention has shifted to neutral molecules, and in particular the chemical mustards in a collaborative project funded by DTRA (Office of Chemical and Biological Defense B1042831). Mustard recognition is a daunting challenge as these molecules are highly reactive under aqueous conditions, but they are not necessarily prone to molecular recognition in their neutral state.
S. O. Kang, J. M. Llinares, V. W. Day, and K. Bowman-James, Cryptand-like Anion Receptors, Chem. Soc. Rev. 2010, 39, 3980-4003.
S. O. Kang, V. W. Day, and K. Bowman-James, Fluoride: Solution- and Solid-State Structural Binding Probe. J. Org. Chem. 2010, 75(2), 277-283.
S. O. Kang, V. W. Day, and K. Bowman-James, Tricyclic Hosts for Linear Anions, Inorg. Chem. 2010, 49, 8629-8636.
Q.-Q. Wang, V. W. Day, K. Bowman-James, Tunable, Shape-shifting Capsule for Dicarboxylates, Chem. Sci. 2011, 2, 1735-1738. DOI: 10.1039/C1SC00292A (Top 10 most accessed articles in July 2011.)
Q.-Q. Wang, R. A. Begum, V. W. Day, K. Bowman-James, Molecular Thioamide ↔ Iminothiolate Switches for Sulfur Mustards, Inorg. Chem. 2012, 51 (2), 760–762. DOI: 10.1021/ic202087u
Q.-Q. Wang, V. W. Day, K. Bowman-James, Supramolecular Encapsulation of Tetrahedrally Hydrated Guests in a Tetrahedron Host, Angew. Chem. Int. Ed. 2012, 2119–2123. DOI: 10.1002/anie.201106090
M. A. Hossain, S. O. Kang, J. A. Kut, V. W. Day, K. Bowman-James, Influence of Charge on Anion Receptivity in Amide-Based Macrocycles, Inorg. Chem. 2012, 51, 4833-4840.
Q.-Q. Wang, R. A. Begum, V. W. Day, K. Bowman-James, Sulfur, oxygen and nitrogen mustards: stability and reactivity, Org. & Biomolec. Chem. 2012, 10(44), 8766-8793.
Q.-Q. Wang, V. W. Day, K. Bowman-James, Chemistry and Structure of a Host Guest Relationship: The Power of NMR and X-ray Diffraction in Tandem, J. Am. Chem. Soc. 2013, 135(1), 392-399.
Q.-Q. Wang, R. A. Begum, K. Bowman-James, Alfred Werner’s expanded legacy: Anion and metal ion coordination in an unsymmetrical, octaamido cryptand, Polyhedron, 2013, Ahead of Print, DOI: 1016/j.poly.2012.08.042
B. A. Moyer, R. Custelcean, B. P. Hay, J. L. Sessler, K. Bowman-James, V. W. Day, S.-O. Kang, A Case for Molecular Recognition in Nuclear Separations: Sulfate Separation from Nuclear Wastes, Inorg. Chem., 2013, Ahead of Print, DOI: 10.1021/ic3016832
Supramolecular Chemistry of Anions, A. Bianchi, K. Bowman-James, E. García-España, Eds. Wiley-VCH: New York, 1997, 461 pp.
Anion Coordination Chemistry, K. Bowman-James, A. Bianchi, E. García-España, Eds., Wiley-Interscience, 2012, 560 pp.